Three major pathophysiologic hypotheses have been proposed to explain the clinical findings of polycystic ovary syndrome pcos related to three major laboratory findings. Department of pharmacology, vinayaka missons college of pharmacy, vinayaka. Subsequent studies have supported and amplified this hypothesis. Polycystic ovarian syndrome pcos is one of the most common female endocrine disorders. There are several mechanisms that have been suggested to play a role in the pathogenesis of pcos, including hormonal. The name of the condition comes from the appearance of numerous small cysts along the outer edge of each ovary and enlarged ovaries. Various diagnostic criteria have been proposed, generally centered. Polycystic ovary syndrome is the most common endocrinopathy among reproductiveaged women in. Polycystic ovary syndrome pcos, also known as the steinleventhal syndrome, is one of the most common endocrinopathies among women of reproductive age. It is characterized by clinical andor biochemical hyperandrogenism, ovulation abnormalities and the presence of enlarged andor polycystic ovaries in ultrasound images 12 or more small bubbles located circumferentially andor ovarian volume 10 ml. Polycystic ovary syndrome pcos, a complex genetic condition, is a highly prevalent heterogeneous syndrome of clinical andor biochemical androgen excess, ovulatory dysfunction and polycystic.
Fogue and massabuau proposed 3 potential mechanisms. Polycystic ovary syndrome pcos is the most common endocrine disorder among female in reproductive age. The diagnosis of polycystic ovary syndrome has emerged. Polycystic ovary syndrome pcos is one of the most common endocrine and metabolic disorders in premenopausal women. Polycystic ovary syndrome pcos accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women. When defined as otherwise unexplained hyperandrogenic oligoanovulation, twothirds of pcos cases have functionally.
Due to the complex pathophysiology involving multiple pathways and proteins, single. Pathophysiology and infertility article pdf available in world journal of laparoscopic surgery 71. The heterogeneity of both the ovarian morphology and clinical. Polycystic ovary syndrome pcos is the most common endocrine disorder in reproductive aged women, with a prevalence between 5% and 15%, depending on the diagnostic criteria applied 1, 2. The rotterdam eshreasrmsponsored pcos consensus work shop group. Polycystic ovary syndrome pcos was hypothesized to result from functional ovarian hyperandrogenism foh due to dysregulation of androgen secretion in 19891995. Development of an animal model for polycystic ovarian. Matalliotakis i1, kourtis a, koukoura o, panidis d.
The disorder is diagnosed if 2 of the 3 specified conditions are met. The diagnosis of pcos has lifelong implications, with increased risk for infertility, metabolic syndrome, and type 2 diabetes mellitus, and possibly for cardiovascular disease and endometrial carcinoma. Polycystic ovary syndrome pcos, like numerous complex diseases, has a multifaceted etiology and pathophysiology, and it is associated with hormonal and metabolic impairments, ovarian. Diagnosis and treatment of polycystic ovary syndrome american. Various diagnostic criteria have been proposed, generally centered around the features of hyperandrogenism andor hyperandrogenemia, oligoovulation and polycystic ovarian morphology. The pathophysiology of pcos is yet to be fully understood. Heterogeneous by nature, pcos is defined by a combination of signs and symptoms of androgen excess and ovarian dysfunction in the absence of other specific diagnoses.
Pcos could be diagnosed by infertility, acne, amenorrhea or. Full text genetic basis of polycystic ovary syndrome pcos. The aetiology of this syndrome remains largely unknown, but mounting evidence suggests that pcos. It is clear that the underlying pathophysiology of pcos is not fully.
Polycystic ovary syndrome pcos is one of the most common endocrine metabolic disorders affecting about 5% women of reproductive age 1. Although the pathophysiology of the syndrome is complex and there is no single defect from which it is. Department of pharmacology and toxicology, swamy vivekanandha college of pharmacy, tiruchengode, namakkal, tamil nadu 637 205, india. Polycystic ovary syndrome and the differential diagnosis of. Polycystic ovary syndrome pcos is a heterogeneous disorder of uncertain aetiology, which affects between 6 and 10% of women of the reproductive age. Development of an animal model for polycystic ovarian syndrome in relation to reproductive and metabolic phenotype. In pcos, the eggs in these follicles do not mature and are not released from the ovaries. Polycystic ovary syndrome pcos is the most common endocrinopathy in women of reproductive age, with a prevalence of up to 10%. Polycystic ovary syndrome pcos is a common endocrine disorder in females, especially in women of reproductive age. An abnormality in the ovaries is the primary cause of the disorder, but additional agents, such as obesity and.378 923 947 411 658 486 126 593 243 1509 732 1441 143 1333 507 492 672 285 74 336 154 455 872 1008 559 265 380 1304 408 957 1032 2